Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)
Multiplex Assay Kit for Procollagen I N-Terminal Propeptide (PINP) ,etc. by FLIA (Flow Luminescence Immunoassay)
P1NP; N-Propeptide Of Type I Procollagen; Procollagen I Amino Terminal Propeptide
（注：?jiǎn)未位鞙y(cè)多因子不超過(guò)8個(gè)指標(biāo) ）
- 編號(hào)LMA957Hu
- 物種Homo sapiens (Human，人) 相同的名稱，不同的物種。
- 實(shí)驗(yàn)方法競(jìng)爭(zhēng)抑制
- 反應(yīng)時(shí)長(zhǎng)1.5h
- 檢測(cè)范圍0.2-200ng/mL
- 靈敏度最小可檢測(cè)劑量小于等于0.067 ng/mL.
- 樣本類型Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids
- 下載 英文說(shuō)明書 中文說(shuō)明書
- 規(guī)格 8指標(biāo)數(shù) 7指標(biāo)數(shù) 6指標(biāo)數(shù) 5指標(biāo)數(shù) 4指標(biāo)數(shù) 3指標(biāo)數(shù) 2指標(biāo)數(shù)1指標(biāo)數(shù)
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通過(guò)ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
特異性
本試劑盒用于檢測(cè)Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)，經(jīng)檢測(cè)與其它相似物質(zhì)無(wú)明顯交叉反應(yīng)。
由于受到技術(shù)及樣本來(lái)源的限制，不可能完成對(duì)所有相關(guān)或相似物質(zhì)交叉反應(yīng)檢測(cè)，因此本試劑盒有可能與未經(jīng)檢測(cè)的其它物質(zhì)有交叉反應(yīng)。
回收率
分別于定值血清及血漿樣本中加入一定量的Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)（加標(biāo)樣品），重復(fù)測(cè)定并計(jì)算其均值，回收率為測(cè)定值與理論值的比率。
| 樣本 | 回收率范圍(%) | 平均回收率(%) |
| serum(n=5) | 78-90 | 80 |
| EDTA plasma(n=5) | 93-105 | 96 |
| heparin plasma(n=5) | 87-95 | 91 |
| sodium citrate plasma(n=5) | 93-101 | 98 |
精密度
精密度用樣品測(cè)定值的變異系數(shù)CV表示。CV(%) = SD/mean×100
批內(nèi)差：取同批次試劑盒對(duì)低、中、高值定值樣本進(jìn)行定量檢測(cè),每份樣本連續(xù)測(cè)定20 次，分別計(jì)算不同濃度樣本的平均值及SD值。
批間差：選取3個(gè)不同批次的試劑盒分別對(duì)低、中、高值定值樣本進(jìn)行定量測(cè)定，每個(gè)樣本使用同一試劑盒重復(fù)測(cè)定8次，分別計(jì)算不同濃度樣本的平均值及SD值。
批內(nèi)差： CV<10%
批間差： CV<12%
線性
在定值血清及血漿樣本內(nèi)加入適量的Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)，并倍比稀釋成1:2，1:4，1:8，1:16的待測(cè)樣本，線性范圍即為稀釋后樣本中Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)含量的測(cè)定值與理論值的比率。
| 樣本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 87-98% | 92-104% | 81-94% | 82-95% |
| EDTA plasma(n=5) | 78-94% | 85-103% | 85-99% | 80-97% |
| heparin plasma(n=5) | 98-105% | 86-102% | 89-98% | 83-104% |
| sodium citrate plasma(n=5) | 78-93% | 93-102% | 84-97% | 78-90% |
穩(wěn)定性
經(jīng)測(cè)定，試劑盒在有效期內(nèi)按推薦溫度保存，其活性降低率小于5%。
為減小外部因素對(duì)試劑盒破壞前后檢測(cè)值的影響，實(shí)驗(yàn)室的環(huán)境條件需盡量保持一致，尤其是實(shí)驗(yàn)室內(nèi)溫度、濕度及溫育條件。其次由同一實(shí)驗(yàn)員來(lái)進(jìn)行操作可減少人為誤差。
實(shí)驗(yàn)流程
1. 實(shí)驗(yàn)前標(biāo)準(zhǔn)品、試劑及樣本準(zhǔn)備；
2. 加樣（標(biāo)準(zhǔn)品、樣本、磁珠、檢測(cè)溶液A）標(biāo)準(zhǔn)品或樣本50μL及磁珠10μL，加檢測(cè)溶液A50μL，
37°C酶標(biāo)板振蕩器孵育60分鐘；
3. 磁吸洗板3次；
4. 加檢測(cè)溶液B100μL，37°C振動(dòng)孵育30分鐘；
5. 磁吸洗板3次；
6. 加鞘液100μL，旋渦震蕩2分鐘后讀數(shù)。
實(shí)驗(yàn)原理
將Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)抗體包被于磁珠，制成固相載體，向微孔中分別加入標(biāo)準(zhǔn)品或標(biāo)本以及磁珠、標(biāo)記VEGFA，標(biāo)記的Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)和未標(biāo)記的Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)與連接于固相載體上的抗體競(jìng)爭(zhēng)結(jié)合，然后將未結(jié)合物洗凈后，加入PE標(biāo)記的親和素，再次徹底洗滌后即可上機(jī)讀數(shù)。MFI值和樣品中的Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法)呈負(fù)相關(guān)。
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| 編號(hào) | 適用物種：Homo sapiens (Human，人) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| RPA957Hu02 | Ⅰ型前膠原氨基端原肽(PINP)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA957Hu61 | Ⅰ型前膠原氨基端原肽(PINP)活性蛋白 | Cell?culture;?Activity?Assays. |
| RPA957Hu01 | Ⅰ型前膠原氨基端原肽(PINP)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA957Hu61 | Ⅰ型前膠原氨基端原肽(PINP)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| SPA957Hu02 | Ⅰ型前膠原氨基端原肽(PINP)合成多肽 | Immunogen; Blocking Peptide. |
| CPA957Hu12 | Ⅰ型前膠原氨基端原肽(PINP)牛血清白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA957Hu32 | Ⅰ型前膠原氨基端原肽(PINP)鑰孔血藍(lán)蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA957Hu31 | Ⅰ型前膠原氨基端原肽(PINP)鑰孔血藍(lán)蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA957Hu22 | Ⅰ型前膠原氨基端原肽(PINP)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA957Hu23 | Ⅰ型前膠原氨基端原肽(PINP)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA957Hu21 | Ⅰ型前膠原氨基端原肽(PINP)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| SPA957Hu01 | Ⅰ型前膠原氨基端原肽(PINP)合成多肽 | Immunogen; Blocking Peptide. |
| CPA957Hu11 | Ⅰ型前膠原氨基端原肽(PINP)牛血清白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| PAA957Hu08 | Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體 | WB; IHC; ICC; IP. |
| PAA957Hu09 | Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體 | WB; IHC; ICC; IP. |
| PAA957Hu01 | Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體 | WB; IHC; ICC; IP. |
| PAA957Hu02 | Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體 | WB; IHC; ICC; IP. |
| LAA957Hu81 | Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體(異硫氰酸熒光素標(biāo)記) | WB; IHC; ICC; IF. |
| LAA957Hu71 | Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體(生物素標(biāo)記) | WB; IHC; ICC. |
| MAA957Hu22 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB |
| RAA957Hu23 | Ⅰ型前膠原氨基端原肽(PINP)重組抗體 | WB; IF; ICC; IHC; IP; FCM. |
| RAA957Hu22 | Ⅰ型前膠原氨基端原肽(PINP)重組抗體 | WB; IF; ICC; IHC; IP; FCM. |
| MAA957Hu24 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB; IHC; ICC; IP. |
| MAA957Hu21 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB,IHC |
| MAA957Hu28 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB; IHC |
| MAA957Hu23 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB; IHC; ICC; IP. |
| MAA957Hu25 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB; IHC; ICC; IP. |
| MAA957Hu27 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB; IHC; ICC; IP. |
| MAA957Hu29 | Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體 | WB; IHC; ICC; IP. |
| SEA957Hu | Ⅰ型前膠原氨基端原肽(PINP)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| IEA957Hu | Ⅰ型前膠原氨基端原肽(PINP)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法,快捷型) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CEA957Hu | Ⅰ型前膠原氨基端原肽(PINP)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA957Hu | Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
| PSA957Hu01 | Ⅰ型前膠原氨基端原肽(PINP)抗體對(duì) | ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays. |
| KSA957Hu11 | Ⅰ型前膠原氨基端原肽(PINP)檢測(cè)試劑盒DIY材料(酶聯(lián)免疫吸附試驗(yàn)法) | Main materials for "Do It (ELISA Kit) Yourself". |
| KSA957Hu01 | Ⅰ型前膠原氨基端原肽(PINP)檢測(cè)試劑盒DIY材料(酶聯(lián)免疫吸附試驗(yàn)法) | 自己動(dòng)手制作ELISA試劑盒的主要材料 |
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| JOURNAL OF THROMBOSIS AND THROMBOLYSIS | Extracellular matrix collagen biomarkers levels in patients with chronic thromboembolic pulmonary hypertension [Pubmed: 33175289] |
| INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | Development of a novel polysaccharide-based iron oxide nanoparticle to prevent iron accumulation-related osteoporosis by scavenging reactive oxygen?… [Pubmed: 33049237] |
| journal of bone and mineral research | Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone‐specific phenotype [Pubmed: 32369212] |
| Endokrynologia Polska | FGF23 and primary hyperparathyroidism: is there a link? [Pubmed: 32598019] |
| Journal of Orthopaedic Translation | Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomized rats [] |
| Research square | 4-Hexylresorcinol Inhibits Osteoclastogenesis by Suppressing NF‐κB Signaling Pathway and Reverses Bone Loss in Ovariectomized Mice [] |
| 淫羊藿水提物及提取藥渣的抗骨質(zhì)疏松藥效比較研究 [] | |
| Pamukkale T?p Dergisi | Postmenapozal Tip-2 diyabetes mellitus' lu hastalarda osteoporoza ba?l? k?r?k riskinin ve kemik Turnoveri'nin de?erlendirilmesi [] |
| International Journal of Pharmaceutical and Clinical Research | Bone Turnover Markers in Osteogenesis Imperfecta and Effect of Bisphosphonate Treatment: First Egyptian Study [] |
| Science Advances | A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair [33310848] |
| Rheumatology | Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis [33221885] |
| Nutrients | Low Energy Availability with and without a High-Protein Diet Suppresses Bone Formation and Increases Bone Resorption in Men: A Randomized Controlled Pilot ?- [33671093] |
| J Bone Miner Res | Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/|??\catenin pathway [33950533] |
| Phytomedicine | Randomized, double-blind, placebo-controlled trial to examine the safety, pharmacokinetics and effects of Epimedium prenylflavonoids, on bone specific alkaline?… [34352588] |
| Nutrients | The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized?… [34684621] |
| PLoS One | Osteoblast-specific inactivation of p53 results in locally increased bone formation [34793446] |
| Bone Res | The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV [34759273] |
| Nutrients | The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized?… [34578973] |
| Chronobiol Int | Night shift work and osteoporosis-bone turnover markers among female blue-collar workers in Poland [Pubmed:35139709] |
| Cancers (Basel) | Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells [Pubmed:35158823] |
| Cell Death Discov | BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis [Pubmed:35523787] |
| Experimental and Molecular Medicine | Foxf2 represses bone formation via Wnt2b/β-catenin signaling [Pubmed:35668101] |
| Bioactive Materials | Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles [Pubmed:35386445] |
| Journal of Orthopaedic Translation | Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway [Pubmed:35228997] |
| Bioactive Materials | Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg–Ca–Zn–Ag alloy to inhibit bacterial infection and promote?… [Pubmed:35585377] |
| Journal of Orthopaedic Translation | Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35?… [] |
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