Gremlin 1蛋白(GREM1)單克隆抗體
Monoclonal Antibody to Gremlin 1 (GREM1)
PIG2; CKTSF1B1; DAND2; IHG-2; DAND2; DRM; Increased in high glucose protein 2; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1
- 編號MAC128Hu21
- 物種Homo sapiens (Human，人) 相同的名稱，不同的物種。
- 來源單抗制備
- 宿主小鼠
- 效價(克隆號)D3
- Ig亞型 IgG1 Kappa
- 純化方式蛋白A + 蛋白G親和純化
- 標記物無標記物
- 免疫原 RPC128Hu02-Gremlin 1蛋白(GREM1)重組蛋白
- 緩沖液成份0.01M 磷酸鹽緩沖液（pH7.4，containing 0.05% Proclin-300，50% glycerol）
- 性狀液體
- 濃度1mg/ml
- 且適物種Sus scrofa; Porcine (Pig，豬)
- 應(yīng)用WB; IHC; ICC; IP.
如果抗體需用于流式細胞術(shù)，請參見流式抗體。 - 下載 英文說明書 中文說明書
- 規(guī)格 20μl100μl 200μl 1ml 10ml
- 價格 ¥ 688 ¥ 1604 ¥ 2292 ¥ 5730 ¥ 22920
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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DAB staining on IHC-P; Sample: Human Kidney Tissue; Primary Ab: 20μg/ml Mouse Anti-Human GREM1 Antibody Second Ab: 2μg/mL?HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: SAA544Mu19)
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通過ISO 9001、ISO 13485質(zhì)量體系認證
特異性
該抗體是針對GREM1的小鼠單克隆抗體。在免疫組織化學(xué)染色和免疫印跡實驗中能識別GREM1。
用法
Western blotting: 0.5-2μg/mL;
Immunohistochemistry: 5-20μg/mL;
Immunocytochemistry: 5-20μg/mL;
Optimal working dilutions must be determined by end user.
儲存
經(jīng)常使用則4°C保存。-20°C保存不超過兩年。避免反復(fù)凍融。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲，損失率低于5%。
贈品
增值服務(wù)
相關(guān)產(chǎn)品
| 編號 | 適用物種：Homo sapiens (Human，人) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| APC128Hu02 | Gremlin 1蛋白(GREM1)活性蛋白 | Cell?culture;?Activity?Assays. |
| RPC128Hu01 | Gremlin 1蛋白(GREM1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| APC128Hu01 | Gremlin 1蛋白(GREM1)活性蛋白 | Cell?culture;?Activity?Assays. |
| RPC128Hu02 | Gremlin 1蛋白(GREM1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAC128Hu01 | Gremlin 1蛋白(GREM1)多克隆抗體 | WB; IHC; ICC; IP. |
| PAC128Hu02 | Gremlin 1蛋白(GREM1)多克隆抗體 | WB; IHC; ICC; IP. |
| LAC128Hu81 | Gremlin 1蛋白(GREM1)多克隆抗體(異硫氰酸熒光素標記) | WB; IHC; ICC; IF. |
| LAC128Hu71 | Gremlin 1蛋白(GREM1)多克隆抗體(生物素標記) | WB; IHC; ICC. |
| MAC128Hu21 | Gremlin 1蛋白(GREM1)單克隆抗體 | WB; IHC; ICC; IP. |
| MAC128Hu23 | Gremlin 1蛋白(GREM1)單克隆抗體 | WB; IHC; ICC; IP. |
| RAC128Hu21 | Gremlin 1蛋白(GREM1)重組抗體 | WB; IF; ICC; IHC; IP; FCM. |
| MAC128Hu22 | Gremlin 1蛋白(GREM1)單克隆抗體 | WB,IHC |
| SEC128Hu | Gremlin 1蛋白(GREM1)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMC128Hu | Gremlin 1蛋白(GREM1)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
參考文獻
| 雜志 | 參考文獻 |
| Lung | Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension [PubMed: 25926293] |
| Tumour Biol | Overexpression of Gremlin promotes non-small cell lung cancer progression [PubMed: 26392110] |
| Int J Cardiol | Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-term prognosis in suspected and proven acute heart failure patients [PubMed: 26539964] |
| International Journal of Cardiology | Triple?head-to-head?comparison?of?fibrotic?biomarkers?galectin-3,?osteopontin?and?gremlin-1?for?long-termprognosis?in?suspected?and?proven?acute?heart?failure?patients [Pubmed:26539964] |
| American Journal of Respiratory Cell and Molecular Biology | BMPR2 Mutation-independent Mechanisms of Disrupted BMP Signaling in IPAH [Pubmed:27187737] |
| J Rheumatol | GREM1 Is a Key ReCavia (Guinea pig )lator of Synoviocyte Hyperplasia and Invasiveness [Pubmed:26834210] |
| European cells & materials | The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells. [pubmed:28266688] |
| Sci Rep. | Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. [pubmed:28327551] |
| American Journal of Respiratory Cell and Molecular Biology | Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial … [rcmb.2015-0402OC] |
| Molecular Medicine Reports | Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells [pubmed:28260028] |
| Cellular Haemostasis and Platelets | Platelets as a novel source of Gremlin-1: Implications for thrombo inflammation [pubmed:27929199] |
| Scientific Reports | Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis [Pubmed: 31053735] |
| International Journal of Molecular Sciences | Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration [Pubmed: 31878307] |
| American Journal of Physiology-Cell Physiology | Suppression of microRNA-23a/b-3p delays the development degenerative joint disease by activating Grem1 and TGF-β/Smad signaling pathway [Pubmed: 32186934] |
| Inflammopharmacology | Protective role of microRNA-23a/b-3p inhibition against osteoarthritis through Gremlin1-depenent activation of TGF-β/smad signaling in chondrocytesa [Pubmed:35441352] |
| Mol Carcinog | CAF‐derived exosomes transmitted Gremlin‐1 promotes cancer progression and decreases the sensitivity of hepatoma cells to sorafenib [Pubmed:35638711] |
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