腎損傷分子1(Kim1)重組蛋白
Recombinant Kidney Injury Molecule 1 (Kim1)
HAVCR1; TIM1; TIMD1; HAVCR; Hepatitis A Virus Cellular Receptor 1; T Cell Immunoglobulin And Mucin Domain-Containing Protein 1; T-cell immunoglobulin mucin receptor 1
- 編號(hào)RPA785Po01
- 物種Sus scrofa; Porcine (Pig，豬) 相同的名稱，不同的物種。
- 來源原核表達(dá)
- 宿主E.coli
- 內(nèi)毒素水平<1.0EU/µg(LAL法測定)
- 亞細(xì)胞定位細(xì)胞膜
- 預(yù)測分子量41.2kDa
- 實(shí)際分子量42kDa(差異分析請(qǐng)參閱說明書)
- 片段與標(biāo)簽Val5~Val107 with N-terminal His and GST Tag
- 緩沖液成份PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
- 性狀凍干粉
- 純度> 80%
- 等電點(diǎn)5.6
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應(yīng)用
Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請(qǐng)參見活性蛋白。 - 下載 英文說明書 中文說明書
- 規(guī)格 10μg50μg 200μg 1mg 5mg
- 價(jià)格 ¥ 912 ¥ 2280 ¥ 4560 ¥ 13680 ¥ 34200
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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Figure. SDS-PAGE
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通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
序列
用法
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
儲(chǔ)存
避免反復(fù)凍融。2-8°C不超過一個(gè)月，-80°C不超過12個(gè)月。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗(yàn)決定，具體方法如下：在37°C孵育48小時(shí)，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲(chǔ)，損失率低于5%。
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相關(guān)產(chǎn)品
| 編號(hào) | 適用物種：Sus scrofa; Porcine (Pig，豬) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| RPA785Po01 | 腎損傷分子1(Kim1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAA785Po01 | 腎損傷分子1(Kim1)多克隆抗體 | WB; IHC; ICC; IP. |
| SEA785Po | 腎損傷分子1(Kim1)檢測試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA785Po | 腎損傷分子1(Kim1)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
參考文獻(xiàn)
| 雜志 | 參考文獻(xiàn) |
| Clinical Toxicology | Clinical implication of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in patients with acute paraquat intoxication [PubMed: 19827907] |
| Pediatric Nephrology | KIM-1 and NGAL: new markers of obstructive nephropathy [SpringerLink: v461592787w5488x] |
| Pediatric Research | Urinary Neutrophil Gelatinase-Associated Lipocalin at Birth Predicts Early Renal Function in Very Low Birth Weight Infants [LWW: 10000] |
| Archives of Medical Science | Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate [AMS: source] |
| Nephrology | Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content [PubMed: 23046363] |
| Nanotoxicology. | Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleate-coated ultra-small superparamagnetic iron oxide (USPIO) and titanium dioxide (TiO(2)) nanoparticles in rats. [PubMed: 23272807] |
| Toxicological Science | A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models [PubMed: PMC3498743] |
| Disease Markers | Interleukin 18 as a Marker of Chronic Nephropathy in Children after Anticancer Treatment [Hindawi: 369784] |
| Journal of Biomarkers | Urinary Measurement of Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 Helps Diagnose Acute Pyelonephritis in a Preclinical Model [Hindawi: 413853] |
| Advances in Life Science and Technology | Kidney injury molecule-1: a urinary biomarker for contrast induced acute kidney injury. [Iiste: Source] |
| Nephrology | Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant [Pubmed: 24325180] |
| Nephrology | Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content. [Pubmed: 23046363] |
| BioMed Research International | The Renal Effects of Vanadate Exposure: Potential Biomarkers and Oxidative Stress as a Mechanism of Functional Renal Disorders—Preliminary Studies [Hindawi: 740105] |
| Life Sci. | Attenuation of renal ischemia/reperfusion injury by a?aí extract preconditioning in a rat model [Pubmed:25476829] |
| Diabetes & Vascular Disease Research | Urinary Kim-1 is a sensitive biomarker for the early stage of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats [Sagepub:Source] |
| 臨床兒科雜志 | 中性粒細(xì)胞明膠酶相關(guān)脂質(zhì)運(yùn)載蛋白、腎損傷分子1和白介素18 在診斷心肺分流術(shù)后急性腎損傷中的意義 [Jcp-Sh:Source] |
| Nephrology (Carlton). | Tubular urinary biomarkers do not identify aetiology of acute kidney injury in kidney transplant recipients [Pubmed:24666430] |
| PLoS One. | Cilostazol Renoprotective Effect: Modulation of PPAR-γ, NGAL, KIM-1 and IL-18 Underlies Its Novel Effect in a Model of Ischemia-Reperfusion [Pubmed:24816434] |
| BMC Nephrology | SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial [Pubmed:24996842] |
| Pediatric Nephrology | The diagnosis of febrile urinary tract infection in children may be facilitated by urinary biomarkers [Pubmed:25127917] |
| Inflammation.? | Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous Crisis [Pubmed:25448261] |
| Transworld Medical Journal | Kidney injury molecule-1: A urinary biomarker for contrast-induced acute kidney injury [Tmjournals:Source] |
| Int J Clin Exp Pathol | Rosiglitazone attenuates renal injury caused by hyperlipidemic pancreatitis [PubMed: 26191125] |
| Int J Clin Exp Pathol | Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice [PubMed: 26045773] |
| Mol Med Rep | Vorinostat protects against calcium oxalate-induced kidney injury in mice [PubMed: 26095064] |
| Pediatr Nephrol | Role of new biomarkers for predicting renal scarring in vesicoureteral reflux: NGAL, KIM-1, and L-FABP [PubMed: 26324091] |
| Journal of Pediatric Urology | Urinary NGAL, KIM-1 and L-FABP concentrations in antenatal hydronephrosis [PubMed: 26096437] |
| Am J Physiol Renal Physiol | Intrarenal Renin-Angiotensin System Mediates Fatty Acid-Induced ER Stress in the Kidney [PubMed: 26672616] |
| Mol Med Rep. | Attenuation of renal ischemia/reperfusion injury by oleanolic acid preconditioning via its antioxidant, anti?inflammatory, and anti?apoptotic activities. [Pubmed:27082705] |
| Nephrol. Dial. Transplant. | Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models [Pubmed:26908768] |
| J Clin Lab Anal.? | Kidney Injury Molecule Levels in Type 2 Diabetes Mellitus [Pubmed:27132791] |
| Med Sci Monit. | Protective Effect of Dihydromyricetin Against Lipopolysaccharide-Induced Acute Kidney Injury in a Rat Model [pmc:PMC4754091] |
| Diabetes. | Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis [Pubmed:26822084] |
| Sci Rep. | Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice [Pubmed:27226136] |
| Journal of Applied Life Sciences International | Vitamins C and E Alleviate Nephrotoxicity-induced by Potassium Bromate in Rats [Barakat812016JALSI28698.pdf] |
| Oxidative Medicine and Cellular Longevity | Synergic Effect of α-Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model. [pubmed:28053694] |
| Molecular Medicine Reports | Attenuation?of?renal?ischemia/reperfusion?injury?by?oleanolic acid?preconditioning?via?itsantioxidant, anti?inflammatory, and anti?apoptotic?activities. [pubmed:27082705] |
| Journal of Agricultural and Food Chemistry | Protective Effects of DHA-PC against Vancomycin-Induced Nephrotoxicity through the Inhibition of Oxidative Stress and Apoptosis in BALB/c Mice [pubmed:29254330] |
| Clin Exp Pharmacol Physiol. | Early urinary biomarkers of renal tubular damage by a high-salt intake independent of blood pressure in normotensive rats. [pubmed:29027259] |
| Nephron - Physiology | Urinary Kidney Injury Molecule-1 but Not Urinary Neutrophil Gelatinase Associated Lipocalin Is Increased after Short Maximal Exercise [10.1159/000481179] |
| Cellular?Physiology and Biochemistry | Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats?… [Pubmed:29550811] |
| Frontiers in Pharmacology | Exploring the therapeutic mechanism of Desmodium styracifolium on oxalate crystal-induced kidney injuries using comprehensive approaches based on?… [Pubmed:29950996] |
| Molecules | Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy [Pubmed:29642511] |
| American Journal of Physiology-Regulatory Integrative and Comparative Physiology | Modeling heart failure risk in diabetes and kidney disease: limitations and potential applications of transverse aortic constriction in high-fat-fed mice [Pubmed:29443547] |
| Biological?Trace?Element?Research | Effect of Aqueous Extract of?Glycyrrhiza glabra?on the Biochemical Changes Induced by Cadmium Chloride in Rats [Pubmed: 30251228] |
| Cancer?Research?and?Treatment | A Phage Display-Identified Peptide Selectively Binds to Kidney Injury Molecule-1(KIM-1) and Detects KIM-1-Overexpressing Tumors in vivo [] |
| Archives?of?Medical?Science | Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, N-acetyl-β-D-glucosaminidase levels and mortality risk in septic patients with?… [Pubmed: 30393493] |
| Biological?&?Pharmaceutical?Bulletin | UPLC/MS-Based Metabolomics Investigation of the Protective Effect of Hydrogen Gas Inhalation on Mice with Calcium Oxalate-Induced Renal Injury [Pubmed: 30381664] |
| Kidney?and?Blood?Pressure?Research | The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy [Pubmed: 30504713] |
| Clinica?Chimica?Acta | Urine markers of renal tubular injury in idiopathic membranous nephropathy: A cross sectional study [Pubmed: 30684459] |
| BMC?Complementary and Alternative Medicine | Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine [Pubmed: 30871515] |
| 2.583 | Application of ELISA Technique and Human Microsomes in the Search for 11β-Hydroxysteroid Dehydrogenase Inhibitors [Doi: BioMed Research International] |
| Naunyn-Schmiedeberg's archives of pharmacology | Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade [Pubmed: 31197431] |
| Egyptian Journal of Zoology | Effect of Cucumis melo var. flexuosus leaves extract on renal oxidative injury and inflammation in diabetic male albino rats [] |
| Environment International | Toxicity assessment due to prenatal and lactational exposure to lead, cadmium and mercury mixtures [Pubmed: 31639605] |
| Bioscience Reports | page Metabolomics study of fasudil on cisplatin-induced kidney injury [Pubmed: 31670380] |
| life sciences | MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury [Pubmed: 31790686] |
| Arch Physiol Biochem | Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats [Pubmed: 31979992] |
| clinical science | Delineating a role for the Mitochondrial Permeability Transition Pore in Diabetic Kidney Disease by targeting Cyclophilin D [Pubmed: 31943002] |
| LIFE SCIENCES | Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway [Pubmed: 32798557] |
| INTERNATIONAL UROLOGY AND NEPHROLOGY | Serum NGAL, KIM-1, IL-18, L-FABP: new biomarkers in the diagnostics of acute kidney injury (AKI) following invasive cardiology procedures [Pubmed: 32557377] |
| Journal of Pediatric Urology | Can Serum Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 Help in Decision Making for Surgery in Antenatally Dedected?… [Pubmed: 33139211] |
| Ratlarda sodyum florid ile olu?turulan toksikasyonda Karvakol'ün b?brekler üzerine etkisi [] | |
| Rationale and design of the intervention in PHOspholamban RElated CArdiomyopathy STudy (i-PHORECAST) [] | |
| Pediatr Int | Early Kidney Injury in Immunoglobulin A Vasculitis: Role of Renal Biomarkers [33423326] |
| J Int Med Res | Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants [33372811] |
| Biomed Res Int | Renal Protective Effect of Beluga Lentil Pretreatment for Ischemia-Reperfusion Injury [33604384] |
| Nutrients | Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide [33922959] |
| J Am Soc Nephrol | Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI [34127536] |
| Heliyon | Anti-oxidant impact of Lisinopril and Enalapril against acute kidney injury induced by doxorubicin in male Wistar rats: involvement of kidney injury molecule-1 [33506137] |
| Journal of Pharmacological Sciences | Pentoxifylline treatment alleviates kidney ischemia/reperfusion injury: Novel involvement of galectin-3 and ASK-1/JNK & ERK1/2/NF-|êB/HMGB-1 trajectories [34030796] |
| Int Urol Nephrol | Could urinary kidney injury molecule-1 be a good marker in subclinical acute kidney injury in mild to moderate COVID-19 infection? [34213713] |
| Intensive Care Medicine Experimental | Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental?… [34169407] |
| iscience | Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure [34820603] |
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