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白介素1ζ(IL1z)活性蛋白

Active Interleukin 1 Zeta (IL1z)

IL1F7; IL37; FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H4; IL-1RP1; IL1H4; IL1RP1; Interleukin 37; Interleukin-1-Related Protein; Interleukin 1 Family, Member 7

  • 白介素1ζ(IL1z)活性蛋白 產(chǎn)品包裝(模擬)
  • 白介素1ζ(IL1z)活性蛋白 產(chǎn)品包裝(模擬)
  • APE842Hu02.jpg Figure. SDS-PAGE
  • Certificate 通過(guò)ISO 9001、ISO 13485質(zhì)量體系認(rèn)證

活性實(shí)驗(yàn)

Interleukin 37, also known as Interleukin 1 Zeta (IL1z), is an anti-inflammatory cytokine. Interleukines are cytokines that make an important part of immune signaling. It belongs to the interleukin-1 family. IL-37 plays a role in protecting the body against endotoxin shock, ischemia-reperfusion injury, autoimmune diseases, and cardiovascular diseases. In addition, IL-37 has a potential antitumor effect. Besides, Interleukin 18 Receptor 1 (IL18R1) has been identified as an interactor of IL1z, thus a binding ELISA assay was conducted to detect the interaction of recombinant human IL1z and recombinant human IL18R1. Briefly, IL1z were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100μl were then transferred to IL18R1-coated microtiter wells and incubated for 2h at 37℃. Wells were washed with PBST and incubated for 1h with anti-IL1z pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37℃. Finally, add 50μl stop solution to the wells and read at 450nm immediately. The binding activity of IL1z and IL18R1 was shown in Figure 1, and this effect was in a dose dependent manner.

用法

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

儲(chǔ)存

避免反復(fù)凍融。2-8°C不超過(guò)一個(gè)月，-80°C不超過(guò)12個(gè)月。

穩(wěn)定性

熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗(yàn)決定，具體方法如下：在37°C孵育48小時(shí)，沒(méi)有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲(chǔ)，損失率低于5%。

相關(guān)產(chǎn)品

編號(hào) 適用物種：Homo sapiens (Human，人) 應(yīng)用(僅供研究使用，不用于臨床診斷！)
APE842Hu01 白介素1ζ(IL1z)活性蛋白 Cell?culture;?Activity?Assays.
RPE842Hu01 白介素1ζ(IL1z)重組蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPE842Hu02 白介素1ζ(IL1z)重組蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
APE842Hu02 白介素1ζ(IL1z)活性蛋白 Cell?culture;?Activity?Assays.
PAE842Hu01 白介素1ζ(IL1z)多克隆抗體 WB; IHC; ICC; IP.
PAE842Hu02 白介素1ζ(IL1z)多克隆抗體 WB; IHC; ICC; IP.
LAE842Hu81 白介素1ζ(IL1z)多克隆抗體(異硫氰酸熒光素標(biāo)記) WB; IHC; ICC; IF.
LAE842Hu71 白介素1ζ(IL1z)多克隆抗體(生物素標(biāo)記) WB; IHC; ICC.
MAE842Hu22 白介素1ζ(IL1z)單克隆抗體 WB; IHC; ICC; IP.
SEE842Hu 白介素1ζ(IL1z)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) Enzyme-linked immunosorbent assay for Antigen Detection.
SCE842Hu 白介素1ζ(IL1z)檢測(cè)試劑盒(化學(xué)發(fā)光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
LME842Hu 白介素1ζ(IL1z)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法) FLIA Kit for Antigen Detection.

參考文獻(xiàn)

雜志 參考文獻(xiàn)
Journal of Periodontal Research Levels of interleukin-37 in gingival crevicular fluid, saliva, or plasma in periodontal disease [Pubmed:25399716]
Arthritis research & therapy Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout. [pubmed:27863506]
Thoracic?Cancer? IL‐37 inhibits invasion and metastasis in non‐small cell lung cancer by suppressing the IL‐6/STAT3 signaling pathway [Pubmed:29575809]
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